Aryl Hydrocarbon Receptor anticorps (AA 15-196)

N° du produit ABIN7870783

Cet anticorps anti-Aryl Hydrocarbon Receptor Polyclonal Lapin (ABIN7870783) détecte spécifiquement Aryl Hydrocarbon Receptor dans WB, ELISA et FACS. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Aryl Hydrocarbon Receptor anticorps (AA 15-196) (ABIN7870783)

Antigène: Aryl Hydrocarbon Receptor (AHR)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aryl Hydrocarbon Receptor est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-Aryl Hydrocarbon Receptor anticorps

Épitope: AA 15-196

Fonction: Ah Receptor Antibody / Aryl hydrocarbon Receptor

Purification: Affinity purified

Immunogène: Recombinant rat protein (amino acids R15-Q196) was used as the immunogen for the Ah Receptor antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Ah Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Ah Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Aryl Hydrocarbon Receptor

Antigène: Aryl Hydrocarbon Receptor (AHR)

Autre désignation: Ah Receptor

Sujet: AHR (aryl hydrocarbon receptor), also called bHLHe76, is a member of the family of basic helix-loop-helix transcription factors. AHR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. The AHR gene is mapped on 7p21.1. Estrogenic actions of AHR agonists were detected in wildtype ovariectomized mouse uteri, but were absent in Ahr-/- or Er-alpha -/- ovariectomized mice. Complex assembly and ubiquitin ligase activity of CUL4B(AHR) in vitro and in vivo are dependent on the AHR ligand. In the CUL4B(AHR) complex, ligand-activated AHR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Cd4-positive cells from mice lacking Ahr developed Th17 responses but failed to produce Il22 and did not show enhanced Th17 development. Activation of Ahr during induction of EAE accelerated disease onset and increased pathology in wildtype mice, but not in Ahr-/- mice. The TDO-AHR pathway is active in human brain tumors and is associated with malignant progression and poor survival. Ahr activity within ROR-gamma-t-positive ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae.

UniProt: P41738

Pathways: Regulation of Cell Size