GBX2 anticorps (AA 150-350)

N° du produit ABIN7870924

Cet anticorps anti-GBX2 Monoclonal Souris (Clone GBX2-7235) (ABIN7870924) détecte spécifiquement GBX2 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GBX2 anticorps (AA 150-350) (ABIN7870924)

Antigène: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GBX2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: GBX2-7235

Détail du produit anti-GBX2 anticorps

Épitope: AA 150-350

Fonction: GBX2 Antibody / Gastrulation Brain Homeobox 2 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 150-350) from the human protein was used as the immunogen for the GBX2 antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the GBX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the GBX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur GBX2

Antigène: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Autre désignation: GBX2

Sujet: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes GBX2 and OTX2. GBX2 and OTX2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, GBX2 negatively regulates OTX2 expression along the anterior-posterior axis, GBX2- mutants demonstrate an expanded OTX2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. GBX2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is overexpressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of GBX2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that GBX2 expression may be required for growth of malignant prostate cells.

UniProt: P52951

Pathways: Dopaminergic Neurogenesis