SF3A1 anticorps (AA 16-646)

N° du produit ABIN7871091

L’anticorps anti-SF3A1 Polyclonal Lapin est utilisé pour la détection de SF3A1 dans des échantillons de Poisson zèbre (Danio rerio). Il a été validé pour IF et IHC (p).

Aperçu rapide pour SF3A1 anticorps (AA 16-646) (ABIN7871091)

Antigène: SF3A1 (Splicing Factor 3a, Subunit 1 (SF3A1))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SF3A1 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SF3A1 anticorps

Épitope: AA 16-646

Fonction: Zebrafish Sf3a1 Antibody / Splicing factor 3A subunit 1

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Sf3a1 recombinant protein (amino acids K16-P646) was used as the immunogen for the Zebrafish Sf3a1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Sf3a1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Sf3a1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SF3A1

Antigène: SF3A1 (Splicing Factor 3a, Subunit 1 (SF3A1))

Autre désignation: Sf3a1

Sujet: Zebrafish Sf3a1, also known as splicing factor 3A subunit 1, is a critical component of the spliceosome complex that regulates the removal of introns from pre messenger RNA. Sf3a1 is part of the SF3A protein complex, which works together with the SF3B complex to stabilize the binding of the U2 small nuclear ribonucleoprotein to the branch point sequence during splicing. This step is essential for accurate and efficient splicing, which in turn is vital for the generation of mature and functional messenger RNA transcripts.

Zebrafish Sf3a1 is an ortholog of the human SF3A1 protein and shares significant sequence and functional conservation. Like its human counterpart, zebrafish Sf3a1 is required for normal RNA processing and proper regulation of gene expression. Due to the importance of splicing in controlling developmental and cellular processes, Sf3a1 function is essential during embryogenesis and tissue differentiation.

Currently, there are no known isoforms of zebrafish Sf3a1 that have been characterized, but as with other splicing factors, alternative splicing may generate additional transcript variants that are yet to be fully studied. Research into zebrafish Sf3a1 offers valuable insights into conserved mechanisms of splicing regulation and its roles in development and disease.

Antibodies targeting zebrafish Sf3a1 protein are useful tools for examining spliceosomal assembly, RNA processing, and transcriptional regulation. These antibodies are commonly used in applications such as western blot, immunohistochemistry, immunofluorescence, and ELISA, supporting a broad range of molecular and developmental biology studies.

UniProt: Q90X41

Pathways: Ribonucleoprotein Complex Subunit Organization