WDR37 anticorps (AA 161-451)

N° du produit ABIN7871109

L’anticorps anti-WDR37 Polyclonal Lapin est utilisé pour la détection de WDR37 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, WB et FACS.

Aperçu rapide pour WDR37 anticorps (AA 161-451) (ABIN7871109)

Antigène: WDR37 (WD Repeat Domain 37 (WDR37))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WDR37 est non-conjugé

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-WDR37 anticorps

Épitope: AA 161-451

Fonction: WDR37 Antibody / WD repeat-containing protein 37

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human WDR37 recombinant protein (Position: D161-Q451) was used as the immunogen for the WDR37 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the WDR37 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the WDR37 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur WDR37

Antigène: WDR37 (WD Repeat Domain 37 (WDR37))

Autre désignation: WDR37

Sujet: WDR37 antibody detects WD repeat-containing protein 37, a member of the WD40 domain protein family that serves as a scaffolding component in numerous multiprotein complexes. WD repeat proteins coordinate protein-protein interactions and are involved in processes such as vesicular trafficking, signal transduction, RNA processing, and cell cycle regulation. WDR37 is conserved across species and is characterized by multiple WD40 repeats forming a beta-propeller structure that mediates molecular recognition events. The WDR37 antibody is valuable for studies exploring signal transduction pathways, protein complex assembly, and developmental regulation.

WDR37 is encoded by the WDR37 gene located on human chromosome 10p15.1. The protein is ubiquitously expressed, with higher levels in brain, kidney, and reproductive tissues. Its precise molecular function remains under investigation, but emerging evidence suggests roles in intracellular signaling and vesicle trafficking. Mutations in WDR37 have been linked to a congenital neurodevelopmental disorder featuring craniofacial and ocular anomalies, underscoring its importance in human development. Studies in animal models indicate that Wdr37 contributes to ciliary and cytoskeletal organization, reflecting a potential connection to ciliopathies.

Using the WDR37 antibody, researchers can detect the native ~55 kDa protein via western blot and localize it through immunofluorescence microscopy. Expression analysis demonstrates cytoplasmic and perinuclear localization, consistent with a role in vesicular trafficking. The antibody is also useful in co-immunoprecipitation experiments for identifying interacting partners within signaling and transport complexes. Functional studies are beginning to connect WDR37 with cell cycle progression and protein degradation pathways, suggesting a role in maintaining proteostasis.

WD repeat proteins like WDR37 often act as adaptors within ubiquitin ligase complexes, G-protein signaling pathways, or RNA splicing assemblies. Understanding WDR37 biology could shed light on how these complexes maintain cellular organization and developmental homeostasis. NSJ Bioreagents provides a validated WDR37 antibody optimized for western blot and immunocytochemistry, supporting ongoing research into WD40 domain protein function, developmental biology, and molecular pathology.

UniProt: Q9Y2I8