STRIP2 anticorps (AA 173-507)

N° du produit ABIN7871274

L’anticorps anti-STRIP2 Polyclonal Lapin est utilisé pour la détection de STRIP2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, ELISA et FACS.

Aperçu rapide pour STRIP2 anticorps (AA 173-507) (ABIN7871274)

Antigène: STRIP2 (Striatin Interacting Protein 2 (STRIP2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STRIP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Détail du produit anti-STRIP2 anticorps

Épitope: AA 173-507

Fonction: STRIP2 Antibody / Striatin-interacting protein 2

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human FAM40B/STRIP2 recombinant protein (Position: H173-Q507) was used as the immunogen for the STRIP2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the STRIP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the STRIP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur STRIP2

Antigène: STRIP2 (Striatin Interacting Protein 2 (STRIP2))

Autre désignation: STRIP2

Sujet: STRIP2 antibody detects Striatin-interacting protein 2, a scaffolding protein that functions as a regulatory component of the STRIPAK complex (striatin-interacting phosphatase and kinase complex). STRIP2 integrates protein phosphatase 2A (PP2A) signaling with cytoskeletal organization, cell motility, and developmental signaling. The STRIP2 antibody is used to study PP2A-mediated signal transduction, cell morphology, and organ development.

STRIP2 is encoded by the STRIP2 gene located on human chromosome 7q34. The protein is approximately 92 kilodaltons and shares structural features with STRIP1, including coiled-coil regions that mediate interactions with striatins, kinases, and phosphatases. Through the STRIPAK complex, STRIP2 influences actin dynamics, cell polarity, and cell-cell junction formation.

The STRIP2 antibody identifies a 90-100 kilodalton protein by western blot. STRIP2 functions as a scaffold that couples kinases such as MST1/2 and MAP4Ks to PP2A, thereby controlling phosphorylation-dependent signaling cascades. This coordination regulates tissue growth, planar cell polarity, and morphogenesis.

Loss or mutation of STRIP2 disrupts cytoskeletal organization and leads to abnormal cell migration and tissue formation. In the nervous system, STRIP2 is important for axon outgrowth and synapse development. Studies have linked STRIP2 mutations to congenital myopathies and developmental disorders. In cancer, dysregulated STRIP2 expression has been observed in breast, lung, and prostate tumors, where it may promote invasive behavior.

STRIP2 serves as a crucial adaptor that integrates mechanical and chemical signaling at the cell cortex. Its interactions with the Hippo pathway components connect STRIPAK signaling to growth regulation and organ size control. NSJ Bioreagents provides a validated STRIP2 antibody optimized for its applications facilitating studies of phosphatase regulation, cytoskeletal architecture, and signal coordination.

UniProt: Q9ULQ0