TUBA1A anticorps (AA 18-403)

N° du produit ABIN7871414

Cet anticorps Lapin Polyclonal détecte spécifiquement TUBA1A dans WB, ELISA, IF, IHC (p) et FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TUBA1A anticorps (AA 18-403) (ABIN7871414)

Antigène: TUBA1A (Tuba1a) (Tubulin, alpha 1a (Tuba1a))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TUBA1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-TUBA1A anticorps

Épitope: AA 18-403

Fonction: TUBA1A Antibody / Tubulin Alpha

Purification: Affinity purified

Immunogène: Recombinant human protein (amino acids N18-A403) was used as the immunogen for the TUBA1A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TUBA1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TUBA1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TUBA1A

Antigène: TUBA1A (Tuba1a) (Tubulin, alpha 1a (Tuba1a))

Autre désignation: TUBA1A

Sujet: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: Q71U36

Pathways: Dynamique des Microtubules, M Phase