SRCIN1 anticorps (AA 189-287)

N° du produit ABIN7871525

Cet anticorps Lapin Polyclonal détecte spécifiquement SRCIN1 dans WB, ELISA, FACS et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SRCIN1 anticorps (AA 189-287) (ABIN7871525)

Antigène: SRCIN1 (SRC Kinase Signaling Inhibitor 1 (SRCIN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRCIN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SRCIN1 anticorps

Épitope: AA 189-287

Fonction: SRCIN1 Antibody

Purification: Antigen affinity purified

Immunogène: Amino acids E189-E287 from the human protein were used as the immunogen for the SRCIN1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SRCIN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SRCIN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SRCIN1

Antigène: SRCIN1 (SRC Kinase Signaling Inhibitor 1 (SRCIN1))

Autre désignation: SRCIN1

Sujet: Using yeast 2-hybrid analysis, protein pull-down assays, and mutation analysis, it is showed that the first coiled-coil domain of rat Snip interacted with the N-terminal t-SNARE domain of Snap25 (600322). Biochemical studies demonstrated that Snip was tightly associated with rat brain cytoskeleton. Indirect immunofluorescence and confocal microscopy of rat PC12 pheochromocytoma cells revealed colocalization of Snip with Snap25 in the actin cytoskeleton, particularly in filopodia, lamellipodia, and neuritic extensions, including the tips. Overexpression of Snip or its Snap25-interacting domain inhibited calcium-dependent exocytosis from PC12 cells. It is concluded that SNIP is involved in regulation of neurosecretion, perhaps via its interaction with SNAP25 and the cytoskeleton.

UniProt: Q9C0H9