Recombinant STING/TMEM173 anticorps (AA 190-290)

N° du produit ABIN7871635

Cet anticorps anti-STING/TMEM173 Monoclonal Lapin (Clone STING1-8187R) (ABIN7871635) détecte spécifiquement STING/TMEM173 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant STING/TMEM173 anticorps (AA 190-290) (ABIN7871635)

Antigène: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp STING/TMEM173 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: STING1-8187R

Détail du produit anti-STING/TMEM173 anticorps

Épitope: AA 190-290

Fonction: ERIS Antibody / Endoplasmic reticulum interferon stimulator / STING1

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the ERIS antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the STING1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur STING/TMEM173

Antigène: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Autre désignation: ERIS

Sujet: TMEM173 (transmembrane protein 173), also called STING1 and ERIS (Endoplasmic reticulum interferon) is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

UniProt: Q86WV6

Pathways: Activation of Innate immune Response