NUB1 anticorps (AA 190-543)

N° du produit ABIN7871644

Cet anticorps anti-NUB1 Polyclonal Lapin (ABIN7871644) détecte spécifiquement NUB1 dans WB, ELISA, IHC (p), IF et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris, Singe et Rat.

Aperçu rapide pour NUB1 anticorps (AA 190-543) (ABIN7871644)

Antigène: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Reactivité: Humain, Souris, Singe, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-NUB1 anticorps

Épitope: AA 190-543

Fonction: NUB1 Antibody / NEDD8 ultimate buster 1 / NYREN18

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (K190-D543) was used as the immunogen for the NUB1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NUB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NUB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur NUB1

Antigène: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Autre désignation: NUB1

Sujet: NEDD8 µLtimate buster 1 is a protein that in humans is encoded by the NUB1 gene. This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.

UniProt: Q9Y5A7