SELT anticorps (AA 20-195)

N° du produit ABIN7871841

L’anticorps anti-SELT Polyclonal Lapin est utilisé pour la détection de SELT dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, FACS, WB, IF et IHC (p).

Aperçu rapide pour SELT anticorps (AA 20-195) (ABIN7871841)

Antigène: SELT (Selenoprotein T (SELT))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SELT est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SELT anticorps

Épitope: AA 20-195

Fonction: SELT Antibody / SELENOT

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids S20-S195) was used as the immunogen for the SELT antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SELT antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SELT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SELT

Antigène: SELT (Selenoprotein T (SELT))

Autre désignation: SELT

Sujet: This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Thioredoxin reductase-like selenoprotein T is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5.

UniProt: P62341

Pathways: Cell RedoxHomeostasis