AMBP anticorps (AA 200-353)

N° du produit ABIN7871976

L’anticorps anti-AMBP Monoclonal Souris est utilisé pour la détection de AMBP dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour AMBP anticorps (AA 200-353) (ABIN7871976)

Antigène: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AMBP est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: AMBP-4533

Détail du produit anti-AMBP anticorps

Épitope: AA 200-353

Fonction: AMBP Antibody / Bikunin / Alpha 1 Microglobulin (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 200-353) from the human protein was used as the immunogen for the AMBP antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the AMBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the AMBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur AMBP

Antigène: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Autre désignation: AMBP

Sujet: The AMBP (Alpha-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated Alpha-1-Microglobulin and Bikunin. Alpha-1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, Alpha-1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter-Alpha-trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike Alpha-1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis.

UniProt: P02760