Recombinant Decorin anticorps (AA 200-359)

N° du produit ABIN7871980

Cet anticorps anti-Decorin Monoclonal Souris (Clone rDCN-9075) (ABIN7871980) détecte spécifiquement Decorin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Decorin anticorps (AA 200-359) (ABIN7871980)

Antigène: Decorin (DCN)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Decorin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: RDCN-9075

Détail du produit anti-Decorin anticorps

Épitope: AA 200-359

Fonction: Recombinant DCN Antibody / Decorin (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant human Decorin protein fragment (within amino acids 200-359) was used as the immunogen for the recombinant DCN antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant DCN antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant DCN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Decorin

Antigène: Decorin (DCN)

Autre désignation: DCN

Sujet: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFbeta and is a direct or indirect negative modulator of TGFbeta synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-gamma and TNFAlpha may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process