DBH anticorps (AA 200-400)

N° du produit ABIN7872013

Cet anticorps anti-DBH Monoclonal Souris (Clone DBH-7222) (ABIN7872013) détecte spécifiquement DBH dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour DBH anticorps (AA 200-400) (ABIN7872013)

Antigène: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DBH est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DBH-7222

Détail du produit anti-DBH anticorps

Épitope: AA 200-400

Fonction: Dopamine Beta-Hydroxylase Antibody / DBH

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the Dopamine Beta-Hydroxylase antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the Dopamine Beta-Hydroxylase antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Dopamine Beta-Hydroxylase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur DBH

Antigène: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Autre désignation: Dopamine Beta-Hydroxylase

Sujet: Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer, which is found in the lumen of synaptic vesicles of corresponding nerve cells, where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and Insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A, cyclic AMP, diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1, CREB and AP-1 proteins including c-Fos, c-Jun and JunD.

UniProt: P09172

Pathways: Carbohydrate Homeostasis