MYORG/KIAA1161 anticorps (AA 207-611)

N° du produit ABIN7872108

L’anticorps anti-MYORG/KIAA1161 Polyclonal Lapin est utilisé pour la détection de MYORG/KIAA1161 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, WB et FACS.

Aperçu rapide pour MYORG/KIAA1161 anticorps (AA 207-611) (ABIN7872108)

Antigène: MYORG/KIAA1161 (MYORG) (Myogenesis Regulating Glycosidase (MYORG))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYORG/KIAA1161 est non-conjugé

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-MYORG/KIAA1161 anticorps

Épitope: AA 207-611

Fonction: MYORG Antibody / Myogenesis-regulating glycosidase

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human MYORG recombinant protein (Position: Q207-R611) was used as the immunogen for the MYORG antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MYORG antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MYORG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MYORG/KIAA1161

Antigène: MYORG/KIAA1161 (MYORG) (Myogenesis Regulating Glycosidase (MYORG))

Autre désignation: MYORG

Sujet: MYORG antibody detects Myogenesis-regulating glycosidase, a lysosomal and endoplasmic reticulum-associated enzyme involved in protein processing and neurological function. The UniProt recommended name is Myogenesis-regulating glycosidase (MYORG). This glycosidase is highly conserved and plays a crucial role in the maintenance of glycoprotein homeostasis within neural tissues, particularly astrocytes.

Functionally, MYORG antibody identifies a 714-amino-acid glycosidase belonging to the glycosyl hydrolase family 31. MYORG hydrolyzes terminal sugar residues from oligosaccharides and glycoproteins, participating in lysosomal degradation and protein quality control. It is mainly localized to the endoplasmic reticulum and perinuclear regions, suggesting involvement in post-translational processing rather than extracellular digestion.

The MYORG gene is located on chromosome 9p13.1 and is highly expressed in brain and skeletal muscle. In the central nervous system, MYORG supports astrocyte differentiation and intercellular communication. It is co-regulated with genes controlling lysosomal activity, endoplasmic reticulum homeostasis, and metabolic signaling.

Pathologically, mutations in MYORG cause primary familial brain calcification (PFBC), a neurodegenerative disorder characterized by calcium deposits in basal ganglia and cerebellum. Deficiency in MYORG leads to altered glycosylation and impaired protein turnover in astrocytes. Research using MYORG antibody assists studies of glycoprotein metabolism, lysosomal function, and neurological disease mechanisms.

MYORG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect intracellular glycosidases and neuronal processing enzymes. NSJ Bioreagents provides MYORG antibody reagents optimized for neuroscience, enzymology, and cellular metabolism research.

Structurally, Myogenesis-regulating glycosidase contains a catalytic domain typical of glycosyl hydrolases with conserved acid-base residues, and a C-terminal transmembrane region anchoring it to intracellular membranes. This antibody supports analysis of MYORG's biochemical function and contribution to neurodegenerative disorders.

UniProt: Q6NSJ0

Pathways: Skeletal Muscle Fiber Development