LY6D anticorps (AA 21-111)

N° du produit ABIN7872120

L’anticorps anti-LY6D Polyclonal Lapin est utilisé pour la détection de LY6D dans des échantillons de Humain. Il a été validé pour ELISA, WB et IHC.

Aperçu rapide pour LY6D anticorps (AA 21-111) (ABIN7872120)

Antigène: LY6D (Lymphocyte Antigen 6 Complex, Locus D (LY6D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LY6D est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-LY6D anticorps

Épitope: AA 21-111

Fonction: LY6D Antibody / Lymphocyte antigen 6D

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human LY6D recombinant protein (Position: L21-L111) was used as the immunogen for the LY6D antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the LY6D antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the LY6D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur LY6D

Antigène: LY6D (Lymphocyte Antigen 6 Complex, Locus D (LY6D))

Autre désignation: LY6D

Sujet: LY6D antibody detects Lymphocyte antigen 6D, encoded by the LY6D gene. Lymphocyte antigen 6D is a glycosylphosphatidylinositol-anchored cell surface protein of the LY6/uPAR family, expressed in epithelial cells and lymphoid precursors. LY6D antibody provides researchers with a specific reagent for studying epithelial differentiation, lymphoid specification, and cancer biology.

Lymphocyte antigen 6D belongs to a family of GPI-anchored proteins characterized by the LY6/uPAR domain. Research using LY6D antibody has shown that it is expressed in epithelial cells of skin and mucosa, where it contributes to barrier formation and differentiation. In the hematopoietic system, LY6D marks early B cell precursors and distinguishes B lineage commitment from alternative lymphoid fates.

Studies with LY6D antibody have revealed that LY6D serves as a robust marker of B cell development in both mice and humans. Expression of LY6D indicates initiation of the B cell program, allowing identification of common lymphoid progenitors committed to B lineage. This makes LY6D antibody an important tool for immunology research and flow cytometric analysis of hematopoiesis.

Dysregulation of Lymphocyte antigen 6D has been associated with cancer and immune disorders. Research using LY6D antibody has shown that it is overexpressed in squamous cell carcinomas of head, neck, and esophagus, where it promotes tumor growth and invasion. In addition, LY6D has been proposed as a diagnostic biomarker and potential therapeutic target in epithelial cancers. Its expression in immune precursors also makes it relevant in studies of immune reconstitution and leukemia.

LY6D antibody is widely applied in flow cytometry, immunohistochemistry, and western blotting. Flow cytometry identifies B lineage progenitors, immunohistochemistry highlights epithelial expression in normal and tumor tissues, and western blotting quantifies levels across developmental and disease states. These applications make LY6D antibody indispensable for immunology and cancer research.

By providing validated LY6D antibody reagents, NSJ Bioreagents supports studies into epithelial differentiation, B cell biology, and cancer. Detection of Lymphocyte antigen 6D provides researchers with insight into how cell surface antigens regulate immunity and tumor progression.

UniProt: Q14210