Decorin anticorps (AA 212-336)

N° du produit ABIN7872206

Cet anticorps Souris Monoclonal détecte spécifiquement Decorin dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Decorin anticorps (AA 212-336) (ABIN7872206)

Antigène: Decorin (DCN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Decorin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DCN-3521

Détail du produit anti-Decorin anticorps

Épitope: AA 212-336

Fonction: Decorin Antibody

Purification: Protein G affinity

Immunogène: A recombinant human Decorin partial protein (within amino acids 212-336) was used as the immunogen for the Decorin antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Decorin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Decorin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Decorin

Antigène: Decorin (DCN)

Autre désignation: Decorin

Sujet: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFå°3/4 and is a direct or indirect negative modulator of TGFå°3/4 synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-c° and TNFä1/4a may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. The human Decorin gene maps to chromosome 12q21.33 and encodes a 359 amino acid protein.

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process