Splicing Factor 1 anticorps (AA 220-461)

N° du produit ABIN7872350

Cet anticorps Souris Monoclonal détecte spécifiquement Splicing Factor 1 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Splicing Factor 1 anticorps (AA 220-461) (ABIN7872350)

Antigène: Splicing Factor 1 (SF1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Splicing Factor 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: NR5A1-3420

Détail du produit anti-Splicing Factor 1 anticorps

Épitope: AA 220-461

Fonction: SF-1 Antibody / Steroidogenic Factor 1 / NR5A1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 220-461 was used as the immunogen for the SF-1 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Steroidogenic Factor 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Steroidogenic Factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Splicing Factor 1

Antigène: Splicing Factor 1 (SF1)

Autre désignation: SF-1

Sujet: The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. Steroidogenic Factor 1 (SF-1) is considered an orphan nuclear receptor that belongs to subfamily 5. It was found to be a regulator of steroidogenic enzyme gene expression. Oxysterols are suggested as its ligands. It is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF-1 plays an important role in adrenal and gonadal development. SF-1 is highly valuable marker to determine the adrenocortical origin of an adrenal mass.

UniProt: Q13285

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Maintenance of Protein Location