Splicing Factor 1 anticorps (AA 220-461)

N° du produit ABIN7872351

L’anticorps anti-Splicing Factor 1 Monoclonal Souris est utilisé pour la détection de Splicing Factor 1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Splicing Factor 1 anticorps (AA 220-461) (ABIN7872351)

Antigène: Splicing Factor 1 (SF1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Splicing Factor 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NR5A1-3420

Détail du produit anti-Splicing Factor 1 anticorps

Épitope: AA 220-461

Fonction: SF-1 Antibody / Steroidogenic Factor 1 / NR5A1

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 220-461 was used as the immunogen for the SF-1 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Steroidogenic Factor 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Steroidogenic Factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Splicing Factor 1

Antigène: Splicing Factor 1 (SF1)

Autre désignation: SF-1

Sujet: The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. Steroidogenic Factor 1 (SF-1) is considered an orphan nuclear receptor that belongs to subfamily 5. It was found to be a regulator of steroidogenic enzyme gene expression. Oxysterols are suggested as its ligands. It is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF-1 plays an important role in adrenal and gonadal development. SF-1 is highly valuable marker to determine the adrenocortical origin of an adrenal mass.

UniProt: Q13285

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Maintenance of Protein Location