LHB anticorps (AA 24-140)

N° du produit ABIN7872666

L’anticorps anti-LHB Polyclonal Lapin est utilisé pour la détection de LHB dans des échantillons de Poisson zèbre (Danio rerio). Il a été validé pour IHC (p).

Aperçu rapide pour LHB anticorps (AA 24-140) (ABIN7872666)

Antigène: LHB (Luteinizing Hormone beta Polypeptide (LHB))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LHB est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-LHB anticorps

Épitope: AA 24-140

Fonction: Zebrafish Luteinizing hormone beta Antibody / Lhb

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Luteinizing hormone beta recombinant protein (amino acids L24-Y140) was used as the immunogen for the Zebrafish Luteinizing hormone beta antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Luteinizing hormone beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Luteinizing hormone beta antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur LHB

Antigène: LHB (Luteinizing Hormone beta Polypeptide (LHB))

Autre désignation: Luteinizing hormone beta

Classe de substances: Hormone

Sujet: Luteinizing hormone (LH) is a glycoprotein hormone critical for the regulation of reproductive function in vertebrates. It consists of a common alpha subunit and a hormone-specific beta subunit, the latter conferring biological specificity. In zebrafish (Danio rerio), the Lhb gene encodes the beta subunit of LH and plays a key role in the hypothalamic-pituitary-gonadal (HPG) axis.

Zebrafish Lhb is produced by gonadotrope cells in the anterior pituitary and is essential for triggering final oocyte maturation and ovulation in females, as well as steroidogenesis and spermatogenesis in males. Its expression is tightly regulated by gonadotropin-releasing hormone (GnRH) and modulated by sex steroids through feedback mechanisms.

The zebrafish model has been instrumental in dissecting the molecular and developmental regulation of lhb expression. Notably, Lhb mRNA becomes detectable during larval stages and increases during sexual maturation. Functional studies using gene knockout and reporter lines have demonstrated that Lhb is indispensable for fertility, and its disruption results in reproductive failure.

Due to its conserved structure and function, zebrafish Lhb serves as a valuable model for studying reproductive endocrinology, pituitary cell differentiation, and hormone signaling pathways in vertebrates.

UniProt: Q6TCF5

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, C21-Steroid Hormone Metabolic Process