STRN3 anticorps (AA 243-690)

N° du produit ABIN7872774

L’anticorps anti-STRN3 Polyclonal Lapin est utilisé pour la détection de STRN3 dans des échantillons de Souris, Humain et Rat. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour STRN3 anticorps (AA 243-690) (ABIN7872774)

Antigène: STRN3 (Striatin, Calmodulin Binding Protein 3 (STRN3))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STRN3 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-STRN3 anticorps

Épitope: AA 243-690

Fonction: STRN3 Antibody / Striatin 3

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human STRN3 recombinant protein (Position: D243-H690) was used as the immunogen for the STRN3 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the STRN3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the STRN3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur STRN3

Antigène: STRN3 (Striatin, Calmodulin Binding Protein 3 (STRN3))

Autre désignation: STRN3

Sujet: STRN3 antibody detects Striatin-3, a calmodulin-binding scaffold protein that forms part of the striatin-interacting phosphatase and kinase (STRIPAK) complex. The UniProt recommended name is Striatin-3 (STRN3). This adaptor protein coordinates protein phosphatase 2A (PP2A) signaling and regulates cytoskeletal organization, cell migration, and signal transduction.

Functionally, STRN3 antibody identifies an 837-amino-acid protein that serves as a platform for assembling PP2A catalytic and regulatory subunits along with kinases such as MST3 and GCKIII family members. STRN3 modulates dephosphorylation of signaling proteins involved in cell adhesion, polarity, and morphogenesis. Its calmodulin-binding domain enables calcium-dependent regulation of complex formation.

The STRN3 gene is located on chromosome 14q12 and is expressed in various tissues, with particularly high levels in brain and heart. STRN3 participates in diverse signaling pathways, including the Hippo pathway, where it regulates MST1/2 kinase activity and contributes to growth control and organ size regulation. Its scaffold function allows spatial coordination between kinases and phosphatases within signaling microdomains.

Pathologically, aberrant STRN3 activity has been linked to cancer progression, cardiac hypertrophy, and neuronal dysfunction. Dysregulated STRIPAK signaling disrupts phosphorylation balance and cytoskeletal remodeling. STRN3 expression changes have been observed in glioblastoma and colon carcinoma, underscoring its importance in cell growth and motility.

STRN3 antibody is suitable for western blotting, immunofluorescence, and co-immunoprecipitation to identify PP2A-associated signaling complexes. NSJ Bioreagents provides validated STRN3 antibody reagents for research in kinase-phosphatase networks, cytoskeletal regulation, and signal transduction.

Structurally, Striatin-3 includes an N-terminal caveolin-binding motif, coiled-coil regions for oligomerization, a calmodulin-binding site, and WD-repeat domains for protein interactions. This antibody aids studies into STRN3's role as a scaffold coordinating phosphatase and kinase communication across multiple pathways.

UniProt: Q13033

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling