SPON1 anticorps (AA 247-611)

N° du produit ABIN7872810

L’anticorps anti-SPON1 Polyclonal Lapin est utilisé pour la détection de SPON1 dans des échantillons de Humain. Il a été validé pour IHC et ELISA.

Aperçu rapide pour SPON1 anticorps (AA 247-611) (ABIN7872810)

Antigène: SPON1 (Spondin 1 (SPON1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPON1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-SPON1 anticorps

Épitope: AA 247-611

Fonction: SPON1 Antibody / Spondin 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human SPON1 recombinant protein (Position: E247-H611) was used as the immunogen for the SPON1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SPON1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SPON1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SPON1

Antigène: SPON1 (Spondin 1 (SPON1))

Autre désignation: SPON1

Sujet: SPON1 antibody detects Spondin-1, an extracellular matrix protein that promotes cell adhesion, axon guidance, and tissue organization. Spondin-1 is a member of the F-spondin family of secreted glycoproteins that regulate neuronal outgrowth and vascular patterning. The SPON1 antibody is used in neuroscience, developmental biology, and vascular research to study ECM signaling and neural development.

SPON1 is encoded by the SPON1 gene located on human chromosome 11p15.2. The protein is approximately 91 kilodaltons and consists of a signal peptide, reelin domain, thrombospondin type I repeats, and a C-terminal region that mediates cell surface binding. Spondin-1 is secreted into the extracellular matrix where it interacts with integrins and heparan sulfate proteoglycans to promote neurite extension and cell attachment.

A SPON1 antibody can detect a 90-95 kilodalton band by western blot and reveals extracellular and pericellular staining in immunohistochemistry. During embryonic development, Spondin-1 guides commissural axons across the midline and contributes to axonal fasciculation. In adult tissues, it participates in vascular remodeling and ECM integrity. Spondin-1 is also implicated in Alzheimer's disease pathology, where altered expression affects amyloid precursor protein processing.

Beyond neural function, Spondin-1 contributes to chondrogenesis, osteogenesis, and tumor angiogenesis. Its expression is upregulated during wound repair and inflammation, suggesting a role in tissue regeneration. NSJ Bioreagents provides a validated SPON1 antibody, supporting investigations into neuronal growth and extracellular signaling.

UniProt: Q9HCB6