SLAMF7 anticorps (AA 249-335)

N° du produit ABIN7872815

Cet anticorps Souris Monoclonal détecte spécifiquement SLAMF7 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SLAMF7 anticorps (AA 249-335) (ABIN7872815)

Antigène: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SLAMF7 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SLAMF7-3649

Détail du produit anti-SLAMF7 anticorps

Épitope: AA 249-335

Fonction: SLAMF7 Antibody / CS1

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 249-335 from the human protein was used as the immunogen for the SLAMF7 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the SLAMF7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the SLAMF7 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur SLAMF7

Antigène: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Autre désignation: SLAMF7

Sujet: CS1, also known as novel Ly9, SLAMF7, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLC and PI 3K. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.

UniProt: Q9NQ25