N-Cadherin anticorps (AA 25-810)

N° du produit ABIN7872893

Cet anticorps Lapin Polyclonal détecte spécifiquement N-Cadherin dans WB. Il présente une réactivité avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour N-Cadherin anticorps (AA 25-810) (ABIN7872893)

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp N-Cadherin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-N-Cadherin anticorps

Épitope: AA 25-810

Fonction: Zebrafish N-cadherin Antibody / Ncad / Cdh2 / Cadherin 2

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish N-cadherin recombinant protein (amino acids M25-R810) was used as the immunogen for the Zebrafish N-cadherin antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish N-cadherin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish N-cadherin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur N-Cadherin

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Autre désignation: N-cadherin

Sujet: N cadherin, also known as Ncad, cadherin 2 and neural cadherin, is a calcium dependent cell adhesion molecule that plays a critical role in the formation and maintenance of tissue architecture during development. In zebrafish, N cadherin is essential for processes such as gastrulation, neurulation, somite formation, and organ morphogenesis.

Zebrafish N cadherin is the ortholog of the human CDH2 gene, which encodes the same protein. Both zebrafish and human N cadherin are members of the classical cadherin family and share a conserved structure that includes extracellular cadherin repeats, a single transmembrane domain, and a cytoplasmic region that interacts with catenins to link cell adhesion to the actin cytoskeleton.

In zebrafish embryos, N cadherin is expressed in the developing nervous system, heart, somites, and other tissues undergoing epithelial to mesenchymal transitions. It mediates homophilic cell-cell adhesion, ensuring coordinated cell movements and stable tissue organization. Loss of N cadherin function in zebrafish results in severe developmental defects, including impaired brain morphogenesis, defective heart formation, and abnormal cell migration.

Due to its strong evolutionary conservation and fundamental role in cell adhesion and signaling, zebrafish N cadherin is widely used as a model to study developmental biology, tissue engineering, cancer metastasis, and congenital disorders involving cadherin dysfunction.

UniProt: Q90275

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane