PEX1 anticorps (AA 256-1266)

N° du produit ABIN7872941

Cet anticorps Lapin Polyclonal détecte spécifiquement PEX1 dans ELISA, WB, IHC, IF et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PEX1 anticorps (AA 256-1266) (ABIN7872941)

Antigène: PEX1 (Peroxisomal Biogenesis Factor 1 (PEX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEX1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-PEX1 anticorps

Épitope: AA 256-1266

Fonction: PEX1 Antibody / Peroxisome biogenesis factor 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human PEX1 recombinant protein (Position: Q256-R1266) was used as the immunogen for the PEX1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PEX1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PEX1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PEX1

Antigène: PEX1 (Peroxisomal Biogenesis Factor 1 (PEX1))

Autre désignation: PEX1

Sujet: PEX1 antibody detects Peroxisome biogenesis factor 1, an ATPase essential for the assembly and maintenance of functional peroxisomes. Encoded by the PEX1 gene on chromosome 7q21.2, this cytoplasmic AAA-type ATPase facilitates peroxisomal matrix protein import by recycling the peroxisomal targeting receptor PEX5. PEX1 acts in concert with PEX6 to drive the dislocation and recycling of receptor proteins from the peroxisomal membrane back to the cytosol, ensuring continued import of matrix enzymes required for lipid metabolism and detoxification.

PEX1 contains two ATPase domains characteristic of the AAA+ protein family and forms a complex with PEX6 that attaches to the peroxisomal membrane via PEX26. This complex functions as an energy-dependent disassembly machine, resetting the import apparatus after cargo delivery. Proper PEX1 activity is essential for peroxisome maintenance and metabolic homeostasis, including beta-oxidation of very long-chain fatty acids and plasmalogen synthesis.

The PEX1 antibody is widely used in cell biology, metabolism, and genetic disease research to study peroxisomal biogenesis, import machinery, and metabolic regulation. Western blot analysis identifies a 147 kilodalton band corresponding to PEX1, while immunofluorescence shows punctate cytoplasmic staining consistent with peroxisomal localization. This antibody provides a sensitive tool for investigating peroxisomal function and organelle dynamics.

Mutations in PEX1 are the most common cause of Zellweger spectrum disorders, a group of peroxisomal biogenesis disorders leading to severe metabolic dysfunction. Loss of PEX1 disrupts enzyme import, leading to defective peroxisome assembly and accumulation of toxic lipid intermediates. The PEX1 antibody supports studies of peroxisome biology, organelle biogenesis, and genetic metabolic disease. NSJ Bioreagents provides this antibody validated for its applications, ensuring reliability for cellular and metabolic research.

UniProt: O43933