Recombinant BCL6 anticorps (AA 256-389)

N° du produit ABIN7872945

L’anticorps anti-BCL6 Monoclonal Souris est utilisé pour la détection de BCL6 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Recombinant BCL6 anticorps (AA 256-389) (ABIN7872945)

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL6 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Clone: RBCL6-1475

Détail du produit anti-BCL6 anticorps

Épitope: AA 256-389

Fonction: Recombinant Bcl6 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A recombinant human partial protein (amino acids 256-389) was used as the immunogen for this recombinant Bcl6 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant Bcl6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant Bcl6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur BCL6

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Autre désignation: Bcl6

Sujet: Bcl6 antibody recognizes B-cell lymphoma 6 protein, a nuclear transcriptional repressor encoded by the human BCL6 gene. Recombinant Bcl6 antibody detects a zinc finger transcription factor that plays a central role in germinal center formation, B-cell differentiation, and regulation of immune responses. Bcl6 is predominantly localized to the nucleus, where it represses transcription of target genes involved in cell cycle control, DNA damage response, and lymphocyte activation.

Recombinant Bcl6 antibody, also referred to as B-cell lymphoma 6 protein antibody and BCL6 transcription repressor antibody in the literature, targets a member of the BTB-POZ domain zinc finger protein family. Bcl6 contains an N-terminal BTB-POZ domain that mediates transcriptional repression through recruitment of corepressor complexes, as well as multiple C-terminal C2H2-type zinc finger motifs responsible for sequence-specific DNA binding. These structural domains enable Bcl6 to regulate gene expression programs critical for germinal center B-cell proliferation and survival.

The BCL6 gene is located on chromosome 3q27 and is frequently involved in chromosomal translocations in diffuse large B-cell lymphoma and other non-Hodgkin lymphomas. Aberrant expression or mutation of Bcl6 disrupts normal germinal center dynamics and contributes to lymphomagenesis by repressing genes such as TP53 and CDKN1A that are involved in apoptosis and cell cycle arrest.

Bcl6 expression is highly enriched in germinal center B cells and certain T follicular helper cells, reflecting its role in adaptive immunity. In addition to immune regulation, Bcl6 has been implicated in inflammatory signaling pathways and may influence macrophage and dendritic cell function through transcriptional repression of pro-inflammatory genes.

Because of its restricted nuclear expression pattern and strong association with germinal center-derived lymphomas, Bcl6 antibody is widely used in research settings to identify germinal center B cells and to characterize B-cell malignancies. Detection of nuclear Bcl6 supports studies of lymphoid differentiation, tumor classification, and transcriptional regulation mechanisms.

Clone rBCL6/1475 is a recombinant monoclonal antibody designed to target Bcl6 protein in research applications. An antibody to Bcl6 is suitable for detecting nuclear Bcl6 expression and for investigating germinal center biology, transcriptional repression, and lymphoma-related signaling pathways.

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus