HES7 anticorps (AA 26-172)

N° du produit ABIN7872985

Cet anticorps anti-HES7 Polyclonal Lapin (ABIN7872985) détecte spécifiquement HES7 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour HES7 anticorps (AA 26-172) (ABIN7872985)

Antigène: HES7 (Hairy and Enhancer of Split 7 (HES7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HES7 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-HES7 anticorps

Épitope: AA 26-172

Fonction: HES7 Antibody / Hairy and enhancer of split-related protein 7

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human HES7 recombinant protein (Position: D26-R172) was used as the immunogen for the HES7 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HES7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the HES7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur HES7

Antigène: HES7 (Hairy and Enhancer of Split 7 (HES7))

Autre désignation: HES7

Sujet: HES7 antibody detects Hairy and enhancer of split-related protein 7, encoded by the HES7 gene on chromosome 17p13.1. HES7 is a basic helix-loop-helix (bHLH) transcriptional repressor and part of the HES family of Notch effectors. It plays a crucial role in the segmentation clock during somitogenesis, regulating cyclic gene expression that establishes somite boundaries in vertebrate embryos. HES7 functions by binding DNA at N-box and E-box elements, repressing transcription of target genes, including its own promoter, generating negative feedback loops essential for oscillatory expression. These oscillations underlie proper segmentation of the presomitic mesoderm into somites, which give rise to vertebrae and ribs.

Disruption of HES7 expression results in severe developmental defects. Mutations in HES7 are associated with spondylocostal dysostosis, a congenital condition characterized by vertebral segmentation abnormalities and rib malformations. Mouse models confirm that loss of HES7 leads to disrupted somite boundaries and vertebral defects. At the cellular level, HES7 interacts with other transcription factors and repressors to coordinate Notch, Wnt, and FGF pathway signals in the segmentation clock network.

Beyond development, aberrant HES7 expression has been detected in certain cancers, where altered Notch signaling contributes to tumorigenesis. As a transcriptional repressor, HES7 influences differentiation decisions, and dysregulation can promote uncontrolled proliferation. HES7 antibody is therefore valuable for developmental biology studies and for investigating the intersection of Notch signaling with disease pathways.

Experimentally, HES7 antibody is used in immunoblotting, immunohistochemistry, and immunofluorescence to track oscillatory expression patterns in embryonic tissues. It also aids in studying Notch-mediated gene regulatory networks, cyclic transcriptional feedback, and congenital mutation effects. In cancer biology, it helps assess HES7 misexpression and its link to proliferative signaling pathways. NSJ Bioreagents provides HES7 antibody to ensure high-quality detection of this oscillatory transcription factor across research applications.

UniProt: Q9BYE0