MAMDC4 anticorps (AA 26-744)

N° du produit ABIN7873016

Cet anticorps Lapin Polyclonal détecte spécifiquement MAMDC4 dans ELISA, FACS, ICC, IF et WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MAMDC4 anticorps (AA 26-744) (ABIN7873016)

Antigène: MAMDC4 (MAM Domain Containing 4 (MAMDC4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAMDC4 est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)

Détail du produit anti-MAMDC4 anticorps

Épitope: AA 26-744

Fonction: MAMDC4 Antibody / MAM domain-containing protein 4

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human MAMDC4 recombinant protein (Position: N26-R744) was used as the immunogen for the MAMDC4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MAMDC4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MAMDC4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MAMDC4

Antigène: MAMDC4 (MAM Domain Containing 4 (MAMDC4))

Autre désignation: MAMDC4

Sujet: MAMDC4 antibody detects MAM domain-containing protein 4, encoded by the MAMDC4 gene on chromosome 9q34.3. MAMDC4 antibody is commonly used in cell adhesion, signaling, and developmental biology research. MAMDC4 is a transmembrane glycoprotein characterized by the presence of MAM domains (meprin, A5, mu), which mediate cell adhesion and protein-protein interactions. Although its precise functions are not fully defined, MAMDC4 is thought to participate in epithelial integrity, neuronal development, and cell signaling.

Structurally, MAMDC4 is a 104-131 kDa protein with multiple MAM domains, immunoglobulin-like domains, and a single transmembrane segment. These structural motifs are shared with proteins involved in cell adhesion and neural guidance. MAMDC4 localizes to the plasma membrane and may be secreted in some contexts. Expression is enriched in epithelial tissues and developing nervous system.

Functionally, MAMDC4 contributes to cell-cell interactions, adhesion, and extracellular signaling. Its MAM domains mediate protein binding that influences cellular communication and tissue organization. Researchers use MAMDC4 antibody to study epithelial biology, neurodevelopment, and signaling networks.

Clinically, MAMDC4 has been implicated in cancer progression, particularly in colorectal and gastric cancers, where altered expression correlates with invasion and metastasis. Variants in MAMDC4 may also influence susceptibility to developmental disorders and neurological disease, though further research is needed. NSJ Bioreagents provides MAMDC4 antibody to support studies of adhesion, signaling, and disease biology.

Experimentally, MAMDC4 antibody is used in western blotting to detect the 104-131 kDa protein, in immunohistochemistry to analyze epithelial expression, and in immunofluorescence microscopy to visualize membrane localization. Co-immunoprecipitation with MAMDC4 antibody helps identify adhesion and signaling partners.

UniProt: Q6UXC1