GATA4 anticorps (AA 262-321)

N° du produit ABIN7873033

Cet anticorps anti-GATA4 Monoclonal Souris (Clone PCRP-GATA4-1A7) (ABIN7873033) détecte spécifiquement GATA4 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GATA4 anticorps (AA 262-321) (ABIN7873033)

Antigène: GATA4 (GATA Binding Protein 4 (GATA4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GATA4 est non-conjugé

Application: Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: PCRP-GATA4-1A7

Détail du produit anti-GATA4 anticorps

Épitope: AA 262-321

Fonction: GATA4 Antibody / GATA-binding factor 4 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 262-321) from the human protein was used as the immunogen for the GATA4 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the GATA4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the GATA4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur GATA4

Antigène: GATA4 (GATA Binding Protein 4 (GATA4))

Autre désignation: GATA4

Sujet: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. GATA-4 and GATA-6 are found in heart, pancreas and ovary, lung and liver tissues exhibit GATA-6, but not GATA-4, expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

UniProt: P43694

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis