GATA4 anticorps (AA 262-321)

N° du produit ABIN7873034

Cet anticorps Souris Monoclonal détecte spécifiquement GATA4 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour GATA4 anticorps (AA 262-321) (ABIN7873034)

Antigène: GATA4 (GATA Binding Protein 4 (GATA4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GATA4 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: PCRP-GATA4-1A7

Détail du produit anti-GATA4 anticorps

Épitope: AA 262-321

Fonction: GATA4 Antibody / GATA-binding factor 4

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 262-321) from the human protein was used as the immunogen for the GATA4 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the GATA4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the GATA4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur GATA4

Antigène: GATA4 (GATA Binding Protein 4 (GATA4))

Autre désignation: GATA4

Sujet: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. GATA-4 and GATA-6 are found in heart, pancreas and ovary, lung and liver tissues exhibit GATA-6, but not GATA-4, expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

UniProt: P43694

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis