PFKFB4 anticorps (AA 266-296)

N° du produit ABIN7873049

Cet anticorps Lapin Polyclonal détecte spécifiquement PFKFB4 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PFKFB4 anticorps (AA 266-296) (ABIN7873049)

Antigène: PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PFKFB4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PFKFB4 anticorps

Épitope: AA 266-296

Fonction: PFKFB4 Antibody / PFK/FBPase 4

Purification: Antigen affinity

Immunogène: A portion of amino acids 266-296 from the human protein was used as the immunogen for the PFKFB4 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the PFKFB4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the PFKFB4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PFKFB4

Antigène: PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

Autre désignation: PFKFB4

Sujet: PFKFB4, also called 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, is a key enzyme involved in the regulation of cellular metabolism. It acts as a regulator of the glycolysis process, which is the breakdown of glucose into energy. This enzyme is crucial for maintaining the balance between energy production and storage within the cell. Research has shown that dysregulation of PFKFB4 can have profound effects on cellular metabolism and ultimately, overall health. For example, overexpression of PFKFB4 has been linked to increased glycolysis and cancer cell proliferation, making it a potential target for cancer therapy. On the other hand, decreased levels of PFKFB4 have been associated with metabolic disorders such as diabetes. One particularly intriguing aspect of PFKFB4 is its dual function as both a kinase and a phosphatase. This unique feature allows it to not only stimulate glycolysis but also inhibit the breakdown of fructose-2,6-biphosphate, a key activator of glycolysis. This dual role gives PFKFB4 a central position in the complex regulatory network of cellular metabolism.

UniProt: Q16877