HMGCR anticorps (AA 268-842)

N° du produit ABIN7873066

Cet anticorps anti-HMGCR Polyclonal Lapin (ABIN7873066) détecte spécifiquement HMGCR dans WB, ELISA, FACS et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour HMGCR anticorps (AA 268-842) (ABIN7873066)

Antigène: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGCR est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HMGCR anticorps

Épitope: AA 268-842

Fonction: HMG CoA Reductase Antibody / HMGCR

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids H268-V842) was used as the immunogen for the HMG CoA Reductase antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HMG CoA Reductase antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the HMG CoA Reductase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur HMGCR

Antigène: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Autre désignation: HMG CoA Reductase

Sujet: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: P04035

Pathways: AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha