BRSK1 anticorps (AA 269-321)

N° du produit ABIN7873069

Cet anticorps anti-BRSK1 Polyclonal Lapin (ABIN7873069) détecte spécifiquement BRSK1 dans WB, ELISA, IF, IHC (p) et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BRSK1 anticorps (AA 269-321) (ABIN7873069)

Antigène: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRSK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-BRSK1 anticorps

Épitope: AA 269-321

Fonction: BRSK1 Antibody / Brain-selective kinase 1

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids E269-E321) was used as the immunogen for the BRSK1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the BRSK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the BRSK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur BRSK1

Antigène: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Autre désignation: BRSK1

Sujet: BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene. BRSK1 was initially identified as a mammalian homolog to the fission yeast S. pombe Cdr2, a mitosis-regulatory kinase and also shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.

UniProt: Q8TDC3