TMED10 anticorps (AA 27-194)

N° du produit ABIN7873092

L’anticorps anti-TMED10 Polyclonal Lapin est utilisé pour la détection de TMED10 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC, IF et FACS.

Aperçu rapide pour TMED10 anticorps (AA 27-194) (ABIN7873092)

Antigène: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMED10 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-TMED10 anticorps

Épitope: AA 27-194

Fonction: TMED10 Antibody / Transmembrane p24 trafficking protein 10

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human TMP21/TMED10 recombinant protein (Position: R27-M194) was used as the immunogen for the TMED10 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TMED10 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TMED10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TMED10

Antigène: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Autre désignation: TMED10

Sujet: TMED10 antibody detects Transmembrane p24 trafficking protein 10, encoded by the TMED10 gene. Transmembrane p24 trafficking protein 10 is a member of the p24 family of cargo receptors that regulate vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus. TMED10 antibody provides researchers with a reliable reagent to study vesicle transport, protein secretion, and the organization of the early secretory pathway.

Transmembrane p24 trafficking protein 10 is an integral membrane protein with a luminal GOLD domain, a transmembrane region, and a short cytoplasmic tail. Research using TMED10 antibody has shown that it interacts with coat protein complexes COPI and COPII, which mediate vesicle budding and fusion. These interactions allow TMED10 to function as a cargo receptor and regulator of vesicle biogenesis. Its role ensures that proteins are correctly sorted and transported between organelles.

Studies with TMED10 antibody have demonstrated that this protein is essential for the proper trafficking of glycosylphosphatidylinositol anchored proteins and other secretory cargo. Without TMED10, cargo retention and mislocalization occur, disrupting Golgi organization and secretion. This highlights the central importance of TMED10 in maintaining homeostasis of the secretory system.

Dysregulation of Transmembrane p24 trafficking protein 10 has been associated with cancer and neurodegeneration. Research using TMED10 antibody has shown that altered expression modifies the trafficking of growth factor receptors and adhesion molecules, promoting abnormal signaling. Variants in TMED10 have also been linked to altered susceptibility to viral infection, emphasizing its role in cellular defense. These findings underscore its broad physiological and pathological relevance.

TMED10 antibody is commonly used in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry reveals distribution in tissues with active secretion, immunofluorescence highlights Golgi localization, and western blotting quantifies expression levels. These applications make TMED10 antibody a valuable tool for cell biology research.

By providing validated TMED10 antibody reagents, NSJ Bioreagents supports studies into vesicle trafficking, protein secretion, and disease. Detection of Transmembrane p24 trafficking protein 10 provides researchers with insights into how the p24 family of proteins coordinates early secretory pathways.

UniProt: P49755