TIA1 anticorps (AA 279-380)

N° du produit ABIN7873218

L’anticorps anti-TIA1 Monoclonal Souris est utilisé pour la détection de TIA1 dans des échantillons de Humain. Il a été validé pour WB et IF.

Aperçu rapide pour TIA1 anticorps (AA 279-380) (ABIN7873218)

Antigène: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIA1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Clone: TIA1-1313

Détail du produit anti-TIA1 anticorps

Épitope: AA 279-380

Fonction: TIA1 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Amino acids 279-380 from the human protein were used as the immunogen for the TIA1 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the TIA1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the TIA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur TIA1

Antigène: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Autre désignation: TIA1

Sujet: TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.

UniProt: P31483