Senataxin (SETX) (AA 28-2447) anticorps

N° du produit ABIN7873246

Cet anticorps anti-Senataxin Polyclonal Lapin (ABIN7873246) détecte spécifiquement Senataxin dans WB et ELISA. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Senataxin (SETX) (AA 28-2447) anticorps (ABIN7873246)

Antigène: Senataxin (SETX)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA

Détail du produit

Épitope: AA 28-2447

Fonction: SETX Antibody / Senataxin

Purification: Immunogen affinity purified

Immunogène: E.coli-derived mouse SETX recombinant protein (Position: S28-R2447) was used as the immunogen for the SETX antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SETX antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SETX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détail du antigène

Antigène: Senataxin (SETX)

Autre désignation: SETX

Sujet: SETX antibody detects Senataxin, a nuclear RNA/DNA helicase involved in transcription termination, RNA processing, and DNA damage repair. Encoded by the SETX gene on chromosome 9q34.13, this large helicase contains a conserved C-terminal superfamily 1 (SF1) helicase domain that unwinds RNA/DNA hybrids (R-loops) formed during transcription and replication. By resolving R-loops, SETX maintains genomic stability and coordinates proper transcription termination for RNA polymerase II genes.

Senataxin interacts with transcription termination factors, RNA-processing proteins, and DNA repair complexes to integrate transcriptional and genomic maintenance pathways. It facilitates the repair of transcription-associated DNA damage and supports RNA splicing fidelity by ensuring timely R-loop resolution. SETX localizes to nuclear foci associated with active transcription sites and DNA damage response regions.

The SETX antibody is widely used in molecular genetics, neurobiology, and genome stability research to study helicase activity, R-loop metabolism, and transcriptional control. Western blot analysis identifies a 303 kilodalton band corresponding to Senataxin, while immunofluorescence reveals discrete nuclear foci marking transcriptionally active chromatin. This antibody supports investigations into RNA-DNA hybrid regulation and the prevention of replication stress.

Mutations in SETX cause neurological disorders such as ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4), highlighting its role in maintaining neuronal integrity. Dysfunctional Senataxin results in R-loop accumulation, transcriptional stress, and DNA strand breaks. The SETX antibody provides a reliable reagent for exploring the links between transcription, RNA metabolism, and neurodegeneration. NSJ Bioreagents supplies this antibody validated for its applications, ensuring reproducible detection in genome maintenance studies.

UniProt: A2AKX3