Occludin anticorps (AA 282-415)

N° du produit ABIN7873297

Cet anticorps anti-Occludin Monoclonal Souris (Clone OCLN-2181) (ABIN7873297) détecte spécifiquement Occludin dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Occludin anticorps (AA 282-415) (ABIN7873297)

Antigène: Occludin (OCLN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Occludin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: OCLN-2181

Détail du produit anti-Occludin anticorps

Épitope: AA 282-415

Fonction: Occludin Antibody

Purification: Protein G affinity chromatography

Immunogène: A recombinant human partial protein (amino acids 282-415) was used as the immunogen for the Occludin antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Occludin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Occludin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Occludin

Antigène: Occludin (OCLN)

Autre désignation: Occludin

Sujet: Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue, in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.

UniProt: Q16625

Pathways: Cell-Cell Junction Organization, Hepatitis C