Recombinant Occludin anticorps (AA 282-415)

N° du produit ABIN7873298

Cet anticorps Lapin Monoclonal détecte spécifiquement Occludin dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Occludin anticorps (AA 282-415) (ABIN7873298)

Antigène: Occludin (OCLN)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Occludin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: OCLN-8526R

Détail du produit anti-Occludin anticorps

Épitope: AA 282-415

Fonction: Occludin Antibody / OCLN (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A recombinant human protein fragment (within amino acids 282-415) was used as the immunogen for the Occludin antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the Occludin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Occludin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Occludin

Antigène: Occludin (OCLN)

Autre désignation: Occludin

Sujet: Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue, in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.

UniProt: Q16625

Pathways: Cell-Cell Junction Organization, Hepatitis C