RBP4 anticorps (AA 29-148)

N° du produit ABIN7873350

L’anticorps anti-RBP4 Monoclonal Souris est utilisé pour la détection de RBP4 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour RBP4 anticorps (AA 29-148) (ABIN7873350)

Antigène: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RBP4 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: RBP4-4047

Détail du produit anti-RBP4 anticorps

Épitope: AA 29-148

Fonction: RBP4 Antibody / Retinol Binding Protein 4 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 29-148 from the human protein was used as the immunogen for the RBP4 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the RBP4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the RBP4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur RBP4

Antigène: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Autre désignation: RBP4

Sujet: Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

UniProt: P02753

Pathways: Regulatory RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response