Recombinant SOX11 anticorps (AA 300-400)

N° du produit ABIN7873608

L’anticorps anti-SOX11 Monoclonal Lapin est utilisé pour la détection de SOX11 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant SOX11 anticorps (AA 300-400) (ABIN7873608)

Antigène: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SOX11 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: SOX11-3235R

Détail du produit anti-SOX11 anticorps

Épitope: AA 300-400

Fonction: Recombinant SOX11 Antibody (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogène: A portion of amino acids 300-400 from the human protein was used as the immunogen for the recombinant SOX11 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant SOX11 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant SOX11 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur SOX11

Antigène: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Autre désignation: SOX11

Sujet: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

UniProt: P35716

Pathways: Tube Formation