Huntingtin anticorps (AA 3079-3142)

N° du produit ABIN7873734

L’anticorps anti-Huntingtin Polyclonal Lapin est utilisé pour la détection de Huntingtin dans des échantillons de Humain. Il a été validé pour ELISA et IHC (p).

Aperçu rapide pour Huntingtin anticorps (AA 3079-3142) (ABIN7873734)

Antigène: Huntingtin (HTT)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Huntingtin est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Huntingtin anticorps

Épitope: AA 3079-3142

Fonction: HTT Antibody / Huntingtin

Purification: Antigen affinity chromatography

Immunogène: An E.coli-derived human recombinant protein (amino acids R3079-C3142) was used as the immunogen for the HTT antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HTT antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the HTT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Huntingtin

Antigène: Huntingtin (HTT)

Autre désignation: HTT

Sujet: The huntingtin gene, also called HTT or HD (Huntington disease) gene, is the IT15 (interesting transcript 15) gene which codes for a protein called the huntingtin protein. It is mapped to 4p16.3. The protein has no sequence homology with other proteins and is highly expressed in neurons and tests in humans and rodents. HTT upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level, and this gene is required for normal development. The HTT protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the absorption of materials into a cell. HTT was also visualized as punctate staining likely to represent nerve endings. What's more, wildtype HTT may function in the nucleus in the assembly of nuclear matrix-bound protein complexes involved with transcriptional repression and RNA processing.

UniProt: P42858

Pathways: Signalisation PI3K-Akt, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport