N-Cadherin anticorps (AA 308-597)

N° du produit ABIN7873738

Cet anticorps anti-N-Cadherin Monoclonal Rat (Clone MNCD2) (ABIN7873738) détecte spécifiquement N-Cadherin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour N-Cadherin anticorps (AA 308-597) (ABIN7873738)

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Reactivité: Humain, Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp N-Cadherin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MNCD2

Détail du produit anti-N-Cadherin anticorps

Épitope: AA 308-597

Fonction: CD325 Antibody / CDH2 / N-Cadherin

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 308-597 was used as the immunogen for the CD325 antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the CD325 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CD325 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur N-Cadherin

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Autre désignation: CD325

Sujet: Recognizes a protein of ~140 kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

UniProt: P19022

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane