Claudin 18 anticorps (AA 31-261)

N° du produit ABIN7873758

L’anticorps anti-Claudin 18 Polyclonal Lapin est utilisé pour la détection de Claudin 18 dans des échantillons de Humain et Rat. Il a été validé pour WB, ELISA, FACS, IF et IHC (p).

Aperçu rapide pour Claudin 18 anticorps (AA 31-261) (ABIN7873758)

Antigène: Claudin 18 (CLDN18)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 18 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Claudin 18 anticorps

Épitope: AA 31-261

Fonction: Claudin 18 Antibody / CLDN18

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids S31-V261) was used as the immunogen for the Claudin 18 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Claudin 18 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Claudin 18 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Claudin 18

Antigène: Claudin 18 (CLDN18)

Autre désignation: Claudin 18

Sujet: Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

UniProt: P56856

Pathways: Cell-Cell Junction Organization, Hepatitis C