SIGLEC12 anticorps (AA 31-287)

N° du produit ABIN7873776

L’anticorps anti-SIGLEC12 Polyclonal Lapin est utilisé pour la détection de SIGLEC12 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour SIGLEC12 anticorps (AA 31-287) (ABIN7873776)

Antigène: SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGLEC12 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-SIGLEC12 anticorps

Épitope: AA 31-287

Fonction: SIGLEC12 Antibody

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids S31-H287) was used as the immunogen for the SIGLEC12 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the SIGLEC12 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the SIGLEC12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur SIGLEC12

Antigène: SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))

Autre désignation: SIGLEC12

Sujet: Sialic acid-binding Ig-like lectin 12, or Siglec-XII, is a protein that in humans, is encoded by the SIGLEC12 gene. Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.

UniProt: Q96PQ1