PYGL anticorps (AA 313-804)

N° du produit ABIN7873854

L’anticorps anti-PYGL Polyclonal Lapin est utilisé pour la détection de PYGL dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, ELISA, IHC (p) et FACS.

Aperçu rapide pour PYGL anticorps (AA 313-804) (ABIN7873854)

Antigène: PYGL (phosphorylase, Glycogen, Liver (PYGL))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PYGL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-PYGL anticorps

Épitope: AA 313-804

Fonction: PYGL Antibody / Glycogen phosphorylase, Liver

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids K313-K804) was used as the immunogen for the PYGL antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PYGL antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PYGL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PYGL

Antigène: PYGL (phosphorylase, Glycogen, Liver (PYGL))

Autre désignation: PYGL

Sujet: Glycogen phosphorylase, liver form (PYGL), also known as human liver glycogen phosphorylase (HLGP), is an enzyme that in humans is encoded by the PYGL gene on chromosome 14. This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: P06737

Pathways: Carbohydrate Homeostasis, Cellular Glucan Metabolic Process