HIP1R anticorps (AA 316-734)

N° du produit ABIN7873892

Cet anticorps Lapin Polyclonal détecte spécifiquement HIP1R dans WB, ELISA, IF, FACS et IHC (p). Il présente une réactivité avec des échantillons de Humain, Rat, Souris et Singe.

Aperçu rapide pour HIP1R anticorps (AA 316-734) (ABIN7873892)

Antigène: HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))

Reactivité: Humain, Rat, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIP1R est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HIP1R anticorps

Épitope: AA 316-734

Fonction: HIP1R Antibody / Huntingtin-interacting protein 1-related protein

Purification: Affinity purified

Immunogène: An E. coli-derived human protein (amino acids E316-E734) was used as the immunogen for the HIP1R antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the HIP1R antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the HIP1R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur HIP1R

Antigène: HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))

Autre désignation: HIP1R

Sujet: Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene. Huntingtin-interacting protein 1-related protein, or HIP1R, was identified on the basis of its structural homology with Huntingtin-interacting protein 1, or HIP1. Based on its domain structure, HIP1R is a putative endocytosis-related protein. Knockdown of HIP1R impairs the endocytosis of activated epidermal growth factor receptor (EGFR) and the consequent activation of the downstream ERK and Akt proteins. Additionally, HIP1R is a component of the clathrin-coated pits and vesicles, which in part links the endocytic machinery to the actin cytoskeleton. It binds to 3-phosphoinositides via ENTH domains to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. HIP1R deficiency significantly reduces the expression of the ionotropic glutamate receptor GluA1, GluN2A, and GluN2B subunits, but not the GABAA receptor ?1 subunit. Knockdown of HIP1R reduces the amplitude and frequency of the miniature excitatory postsynaptic current, but not of the miniature inhibitory postsynaptic curren. HIP1R has been identified as a protein that can target histone deacetylase-3-mediated neurodegeneration, along with other proteins like NPTX1, NFL, TEX10, and TGFFG.

UniProt: O75146