PGS1 anticorps (AA 33-525)

N° du produit ABIN7874005

Cet anticorps anti-PGS1 Polyclonal Lapin (ABIN7874005) détecte spécifiquement PGS1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour PGS1 anticorps (AA 33-525) (ABIN7874005)

Antigène: PGS1 (Phosphatidylglycerophosphate Synthase 1 (PGS1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PGS1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PGS1 anticorps

Épitope: AA 33-525

Fonction: PGS1 Antibody / Phosphatidylglycerophosphate synthase 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human PGS1 recombinant protein (Position: R33-R525) was used as the immunogen for the PGS1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PGS1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PGS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PGS1

Antigène: PGS1 (Phosphatidylglycerophosphate Synthase 1 (PGS1))

Autre désignation: PGS1

Sujet: PGS1 antibody detects Phosphatidylglycerophosphate synthase 1, encoded by the PGS1 gene on chromosome 17q21.33. PGS1 antibody is widely used in studies of mitochondrial lipid metabolism, cardiolipin biosynthesis, and cellular energy homeostasis. PGS1 encodes a key enzyme in the biosynthetic pathway for phosphatidylglycerophosphate, which is a precursor of phosphatidylglycerol and cardiolipin. These mitochondrial phospholipids are essential for respiratory chain function, mitochondrial morphology, and apoptosis regulation.

Structurally, PGS1 is a ~56 kDa protein localized to the inner mitochondrial membrane. It contains transmembrane domains that anchor it within the lipid bilayer and a catalytic region that mediates condensation of CDP-diacylglycerol with glycerol-3-phosphate. The enzyme operates as part of the mitochondrial lipid biosynthesis machinery, which coordinates the synthesis of cardiolipin required for respiratory chain supercomplex stability.

Functionally, PGS1 generates phosphatidylglycerophosphate, which is dephosphorylated to phosphatidylglycerol and further converted to cardiolipin. Cardiolipin is critical for optimal activity of electron transport chain complexes and mitochondrial dynamics. Disruption of PGS1 function impairs cardiolipin synthesis, leading to defective oxidative phosphorylation, altered mitochondrial morphology, and increased susceptibility to apoptosis. Researchers use PGS1 antibody to study lipid metabolism, mitochondrial function, and cell death pathways.

Clinically, mutations in PGS1 cause mitochondrial disorders characterized by lactic acidosis, developmental delay, and cardiomyopathy. PGS1 deficiency resembles Barth syndrome due to cardiolipin deficiency. Dysregulation of cardiolipin metabolism has been linked to neurodegeneration, cancer, and metabolic diseases. Because cardiolipin plays a role in apoptosis signaling, PGS1 has also been investigated in cancer biology. NSJ Bioreagents supplies PGS1 antibody to support studies of mitochondrial disease, lipid biology, and energy metabolism.

Experimentally, PGS1 antibody is used in western blotting to detect the ~56 kDa protein, in immunohistochemistry to examine mitochondrial distribution in tissues, and in immunofluorescence microscopy to assess subcellular localization. Co-immunoprecipitation with PGS1 antibody identifies interactions with cardiolipin synthase and other lipid biosynthetic enzymes.

UniProt: Q32NB8