ADRA2B anticorps (AA 343-369)

N° du produit ABIN7874107

Cet anticorps anti-ADRA2B Polyclonal Lapin (ABIN7874107) détecte spécifiquement ADRA2B dans WB, IF, FACS et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ADRA2B anticorps (AA 343-369) (ABIN7874107)

Antigène: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRA2B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ADRA2B anticorps

Épitope: AA 343-369

Fonction: Alpha-2B Adrenergic Receptor Antibody / ADRA2B

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 343-369 from the human protein was used as the immunogen for the Alpha-2B Adrenergic Receptor antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Alpha-2B Adrenergic Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Alpha-2B Adrenergic Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ADRA2B

Antigène: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Autre désignation: Alpha-2B Adrenergic Receptor

Sujet: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.

UniProt: P18089

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process