STK39 anticorps (AA 346-376)

N° du produit ABIN7874119

Cet anticorps anti-STK39 Polyclonal Lapin (ABIN7874119) détecte spécifiquement STK39 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour STK39 anticorps (AA 346-376) (ABIN7874119)

Antigène: STK39 (serine threonine Kinase 39 (STK39))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STK39 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-STK39 anticorps

Épitope: AA 346-376

Fonction: SPAK Antibody / STK39

Purification: SAS precipitation

Immunogène: A portion of amino acids 346-376 from the human protein were used as the immunogen for the SPAK antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the SPAK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SPAK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur STK39

Antigène: STK39 (serine threonine Kinase 39 (STK39))

Autre désignation: SPAK

Sujet: SPAK is a serine/threonine kinase containing an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain, a nuclear localization signal, a consensus caspase cleavage recognition motif, and a C-terminal region. Northern blot analysis detects ubiquitous expression, most abundantly in brain and pancreas. SPAK can phosphorylate itself and an exogenous substrate in vitro. SPAK immunoprecipitates from transfected mammalian cells in a complex with another serine/threonine kinase that phosphorylates catalytically inactive SPAK. SPAK activates the p38 MAP kinase pathway in cotransfection assays. Full-length SPAK is expressed in the cytoplasm in transfected cells, while a mutant corresponding to caspase-cleaved STK39 localizes predominantly in the nucleus.

UniProt: Q9UEW8