Vitamin D-Binding Protein anticorps (AA 35-175)

N° du produit ABIN7874135

Cet anticorps Souris Monoclonal détecte spécifiquement Vitamin D-Binding Protein dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Vitamin D-Binding Protein anticorps (AA 35-175) (ABIN7874135)

Antigène: Vitamin D-Binding Protein (GC)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Vitamin D-Binding Protein est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: VDBP-4481

Détail du produit anti-Vitamin D-Binding Protein anticorps

Épitope: AA 35-175

Fonction: VDBP Antibody / Vitamin D binding protein / GC

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 35-175 was used as the immunogen for the VDBP antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the VDBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the VDBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Vitamin D-Binding Protein

Antigène: Vitamin D-Binding Protein (GC)

Autre désignation: VDBP

Sujet: Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.

UniProt: P02774

Pathways: Metabolism of Steroid Hormones and Vitamin D, Monocarboxylic Acid Catabolic Process