PAPPA anticorps (AA 351-523)

N° du produit ABIN7874240

Cet anticorps Souris Monoclonal détecte spécifiquement PAPPA dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PAPPA anticorps (AA 351-523) (ABIN7874240)

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAPPA est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: PAPPA-2715

Détail du produit anti-PAPPA anticorps

Épitope: AA 351-523

Fonction: PAPP-A Antibody / Pappalysin-1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPP-A antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the PAPP-A antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the PAPP-A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur PAPPA

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Autre désignation: PAPP-A

Sujet: Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

UniProt: Q13219